{"id":1096,"date":"2018-04-17T13:09:00","date_gmt":"2018-04-17T11:09:00","guid":{"rendered":"http:\/\/www.microgels.rwth-aachen.de\/?p=1096"},"modified":"2020-01-08T14:56:12","modified_gmt":"2020-01-08T13:56:12","slug":"monitoring-microgel-synthesis-by-copolymerization-of-n-isopropylacrylamide-and-n-vinylcaprolactam-via-in-line-raman-spectroscopy-and-indirect-hard-modeling","status":"publish","type":"post","link":"https:\/\/www.microgels.rwth-aachen.de\/?p=1096","title":{"rendered":"Monitoring microgel synthesis by copolymerization of N-isopropylacrylamide and N-vinylcaprolactam via in-line Raman spectroscopy and Indirect Hard Modeling"},"content":{"rendered":"\n

Functionalized microgels are typically based on structured copolymers, whose synthesis necessitates knowledge of interactions between different monomer units. This contribution presents in-line Raman and turbidity monitoring of copolymer microgels based on monomers N-vinylcaprolactam (VCL) and N-isopropylacrylamide (NIPAM). During reaction, in-line Raman spectra are evaluated via multivariate indirect hard modeling (IHM) regression, utilizing pure component models based on parameterized peak functions. To account for variation in Raman baseline intensity, the linear IHM baseline is replaced by a curved baseline, resulting in calibration R<\/em>\u00b2 above 0.98 and root-mean-squared errors of cross-validation below 0.12 wt%. Spectra taken in-line during microgel syntheses reveal NIPAM to react slower than VCL in homopolymerization, but faster than VCL in copolymerization. This effect can be used for synthesis of functional microgels, that is, with tunable volume phase transition temperature. This effect is not visible from turbidity measurements, demonstrating the advantage of in-line Raman monitoring of chemical components in polymerization processes.<\/p>\n\n\n\n

\"\"<\/a><\/figure><\/div>\n\n\n\n

Julian Meyer-Kirschner, Michael Kather, Agnieszka Ksiazkiewicz, Andrij Pich,<\/em> Alexander Mitsos, and Joern Viell<\/em><\/p>\n\n\n\n

Macromol. Reac. Eng.<\/em>, 12 (3) (2018) DOI: 10.1002\/mren.201700067<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

Functionalized microgels are typically based on structured copolymers, whose synthesis necessitates knowledge of interactions between different monomer units. This contribution<\/p>\n","protected":false},"author":1,"featured_media":1097,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[34],"tags":[],"class_list":["post-1096","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlights"],"author_meta":{"display_name":"sfb985_admin","author_link":"https:\/\/www.microgels.rwth-aachen.de\/?author=1"},"featured_img":"https:\/\/www.microgels.rwth-aachen.de\/wp-content\/uploads\/2019\/12\/GraphicalAbstractViell-300x250.png","coauthors":[],"tax_additional":{"categories":{"linked":["Highlights<\/a>"],"unlinked":["Highlights<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 8 years ago","modified":"Updated 6 years ago"},"absolute_dates":{"created":"Posted on April 17, 2018","modified":"Updated on January 8, 2020"},"absolute_dates_time":{"created":"Posted on April 17, 2018 13:09","modified":"Updated on January 8, 2020 14:56"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/posts\/1096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1096"}],"version-history":[{"count":3,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/posts\/1096\/revisions"}],"predecessor-version":[{"id":1360,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/posts\/1096\/revisions\/1360"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/media\/1097"}],"wp:attachment":[{"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.microgels.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}