C3

Multi-functional microgels targeted towards inflammatory bowel disease (IBD)

In this project, we will develop multifunctional microgels capable of scavenging inflammatory mediators as well as targeting, imaging, and protecting inflamed intestinal tissue. Functionalization of microgel with galectins and adhesion peptides will target the inflamed tissue thereby building a protective microgel layer to prevent secondary bacterial infection. Microgels with scavenging and imaging units will capture the inflammation ligand TNFα and localize at the sites of inflammation. The ultimate goal is to generate therapeutic, diagnostic, and theranostic microgels.

Principle Investigators

Kühne, Alexander, Prof. Dr.
Associated Scientist, Ulm University
DWI – Leibniz Institute for Interactive Materials
RWTH Aachen University
+49 731 50 22870
alexander.kuehne@uni-ulm.de

Elling, Lothar, Prof. Dr.
Helmholtz Institute for Biomedical Engineering
RWTH Aachen University
+49 241 80 28350
l.elling@biotec.rwth-aachen.de

Trautwein, Christian, Prof. Dr. med.
Lehrstuhl für Innere Medizin
Uniklinik RWTH Aachen
+49 241 80 80866
ctrautwein@ukaachen.de

Strnad, Pavel, Priv.-Doz. Dr. med.
Lehrstuhl für Innere Medizin
Uniklinik RWTH Aachen
+49 241 80 35324
pstrnad@ukaachen.de