Microgel-engineered chemoenzymatic cascades employing whole cells

The project aims at developing a reaction platform for cascade reactions involving whole cells (biocatalyst) with bioinorganic catalysts, in which compatible reaction conditions are mediated via microgels. As a biocatalyst, we use yeast cells displaying on their surface a fungal peroxygenase (UPO) to oxidize polycyclic aromatic compounds. Tailored microgel coatings of the yeast cells are expected to provide a modular system, compatible conditions for cascade reactions, and highly efficient reaction conditions. The copper catalysts are also immobilized in microgels to prevent inactivation and to enable catalyzing complex reactions (oxygenation and oxidation) by tight spatial location even at low concentrations and lower temperatures.

Principle Investigators

Schwaneberg, Ulrich, Prof. Dr.
Institute of Biotechnology
RWTH Aachen University
+49 241 80 24170

Herres-Pawlis, Sonja, Prof. Dr.
Institute of Inorganic Chemistry
RWTH Aachen University
Tel. +49 241 80 93902