In a recent concept article published in Small, Richtering, Alberg and Zentel have summarized existing data with the aim to explain the differences in nanoparticles and their influence on the interaction with plasma proteins from a physico-chemical perspective. The authors conclude that the difference between a strongly hydrated/swollen polymer shell versus a sharp “hard” surface and its accessibility are especially relevant for biomedical applications.
Walter Richtering, Irina Alberg and Rudolf Zentel
Small 2020, 2002162, DOI: 10.1002/smll.202002162
The authors’ motivation to look deeper into this topic arose from a recent finding that not all nanosized objects form a so called protein corona in the presence of plasma proteins. Read more on Advanced Science News: